Prophylaxis Approach  

 

Number of Agents to Give 

 

  • Low: No prophylaxis

  • 1-2 risk factors: Give 2 medications  

  • >2 risk factors: Give 3 or more medications 

 

 

Suggested Combination Therapy 

 

  • Never combine drugs from the same class 

  • Most widely studied are 5-HT3 receptor antagonists or butryphenones + dexamethasone.  For example, if giving 2 IV drugs:

    • Ondansetron 4mg + dexamethasone 4mg 

    • Droperidol 0.625 mg + dexamethasone 4mg 

    • Haldol 1 mg + dexamethasone 4mg 

 

 

Therapeutic Options 

 

 

 

 

 

 

 

 

 

 

 

 

Adapted from Anesth Analg. August 2020 - Volume 131 - Issue 2 - p 411-448

 

 

 

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