Antihistamines 

 

Dimenhydrinate

  • 1mg/kg IV (max 50 mg) is recommended dose 

  • NNT 8 (early postop period) and 5 (late postop period)

  • Antiemetic effect may be similar to ondansetron but insufficient studies for optimal timing or dose

 

Promethazine

  • 6.25 mg IV or deep IM injection

  • FDA Black box warning 2009: risk severe tissue damage/gangrene if arterial injection or injected under the skin (interstitial IV)

 

Adapted from Anesth Analg. August 2020 - Volume 131 - Issue 2 - p 411-448

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