Others 

 

Propofol 

 

  • Intraoperative subhypnotic doses at 20mcg/kg/min or higher can reduce PONV by up to 25% 

  • Small doses (20mg PRN) can be used as PONV rescue therapy in PACU 

Gabapentin 

  • Preoperative gabapentin 600-800 mg  decreases PONV 

  • Side effects: sedation, dizziness, respiratory depression, headache

 

Midazolam 

 

  • 2mg IV 30 min prior to end of case as effective as ondansetron 4mg.  Combination of the 2 drugs was even more effective

 

Ephedrine

  • 0.5 mg/kg IM given near end of surgery

  • Similar effect to droperidol 0.04 mg/kg IM

  • Caution if risk of CAD

 

Adapted from Anesth Analg. August 2020 - Volume 131 - Issue 2 - p 411-448