Anesthesia Considerations 

NK-1 Receptor Antagonists 

 

Aprepitant 

 

• 40-80mg PO within 3 hours of induction of anesthesia 

• Routine use not yet established 

• Appears to be more effective than ondansetron in preventing PONV in the first 24-48 hours 

 

Adapted from Anesth Analg. August 2020 - Volume 131 - Issue 2 - p 411-448