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Ventilation therapies


  • Severe TBI pts require definitive airway protection (risk pulm aspiration, compromised resp drive/fxn)

  • Normal ventilation (w/ PaCO2 35-45 mmHg) is currently the goal in absence of cerebral herniation

  • Prolonged prophylactic hyperventilation (PaCO2 ≤25 mmHg) not recommended

  • Hyperventilation may be used as a temporizing measure to ↓ ICP (ex if cerebral herniation)



Adapted from Guidelines for the Management of Severe TBI, 4th Ed., September 2016, Brain Trauma Foundation.

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