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    Anesthesia Considerations 

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    Hyperosmolar therapy

     

    • Useful to ↓ ICP

    • Insufficient evidence to support specific recommendations re type of agent (ex mannitol, hypertonic saline) and means of administration

      • Hypertonic saline may be more effective than mannitol to ↓ ICP but no difference in short-term mortality

     

    Adapted from Guidelines for the Management of Severe TBI, 4th Ed., September 2016, Brain Trauma Foundation.