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Hyperosmolar therapy


  • Useful to ↓ ICP

  • Insufficient evidence to support specific recommendations re type of agent (ex mannitol, hypertonic saline) and means of administration

    • Hypertonic saline may be more effective than mannitol to ↓ ICP but no difference in short-term mortality


Adapted from Guidelines for the Management of Severe TBI, 4th Ed., September 2016, Brain Trauma Foundation.

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