Fluid Therapy in Sepsis 


  • Use dynamic variables to assess fluid-responsiveness 

  • Crystalloids (or a balanced solution or NS) should be first line with an initial bolus of 30cc/kg 

  • Do NOT use hydroxyethyl starches (associated with ↑ morbidity & possible ↑ mortality) 

  • Consider albumin if significant amounts of crystalloid have been used 

  • Continue fluid boluses as long as there are hemodynamic improvements based on either dynamic (e.g. pulse pressure or stroke volume variation) or static variables (e.g. arterial pressure, heart rate) 



Adapted from Surviving Sepsis Guidelines 2016. Critical Care Medicine: March 2017 - Volume 45, Issue 3, p 486–552

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