Factor V Leiden
Background
-
The factor V Leiden mutation results in resistance to activated protein C thus causing thrombosis.
-
Factor V Leiden is the The most common inherited thrombophilia in individuals with venous thromboembolism
-
Other major hereditary disorders linked to hypercoagulability include antithrombin deficiency, protein C and S deficiencies, and prothrombin 20210A
Considerations
-
Patients may be on chronic anticoagulant or antiplatelets agents that may impact perioperative management, including the need for bridging therapy
-
Patients are at increased risk of perioperative clotting events and need a DVT prophylaxis plan
References
-
Adriana OD. Hematologic disorders. In: Hines R, Jones S, editors. Stoelting's Anesthesia and Co-Existing Disease. 8th Edition. Philadelphia, PA: Elsevier; 2021. p. 465-496