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Factor V Leiden 




  • The factor V Leiden mutation results in resistance to activated protein C  thus causing thrombosis.

  • Factor V Leiden is the The most common inherited thrombophilia in individuals with venous thromboembolism

  • Other major hereditary disorders linked to hypercoagulability include antithrombin deficiency, protein C and S deficiencies, and prothrombin 20210A




  • Patients may be on chronic anticoagulant or antiplatelets agents that may impact perioperative management, including the need for bridging therapy

  • Patients are at increased risk of perioperative clotting events and need a DVT prophylaxis plan


  • Adriana OD. Hematologic disorders. In: Hines R, Jones S, editors. Stoelting's Anesthesia and Co-Existing Disease. 8th Edition. Philadelphia, PA: Elsevier; 2021. p. 465-496

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