Definitions (as per Society of Critical Care Medicine & the European Society of Intensive Care Medicine)
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Sepsis: Organ dysfunction caused by a dysregulated host response to infection. Organ dysfunction is ≥2 points on the SOFA score (see below)
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Septic Shock: Patients with sepsis who despite adequate fluid resuscitation, require vasopressors to maintain a mean arterial pressure (MAP) ≥65 mmHg and have a lactate >2 mmol/L
SOFA (Sequential Organ Failure Assessment) Score
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Pulmonary: PaO2/FiO2
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>400 (0 points)
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301 to 400 (1 point)
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≤300 (2 points)
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101 to 200 with ventilatory support (3 points)
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≤100 with ventilatory support (4 points)
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Coagulation: Platelets (/mm3)
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>150K (0 points)
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101-150K (1 point)
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51-100K (2 points)
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21-50K (3 points)
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≤20K (4 points)
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Liver: Bilirubin (mcmol/L)
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20 (0 points)
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20-32 (1 point)
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33-101 (2 points)
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102-204 (3 points)
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>204 (4 points)
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Cardiovascular: Blood Pressure
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Hypotension absent (0 points)
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Mean arterial pressure <70 mmHg (1 point)
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On dopamine ≤5 mcg/kg/min or any dobutamine (2 points)
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On dopamine >5 mcg/kg/min, epinephrine ≤0.1 mcg/kg/min or norepinephrine ≤0.1 mcg/kg/min (3 points)
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On dopamine >15 mcg/kg/min or epinephrine >0.1 mcg/kg/min or norepinephrine >0.1 mcg/kg/min (4 points)
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Brain: GCS Score
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15 (0 points)
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13-14 (1 point)
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10-12 (2 points)
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6-9 (3 points)
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<6 (4 points)
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Kidney: Renal Function
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Creatinine 110 mcmol/L (0 points)
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Creatinine 110-170 mcmol/L (1 point)
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Creatinine 171-299 mcmol/L (2 points)
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Creatinine 300-440 mcmol/L or urine output 200-500 cc/day (3 points)
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Creatinine >440 mcmol/L or urine output <200 cc/day (4 points)
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