Anesthesia Considerations 

Acute Leukemia 

 

 

 

Considerations

 

• Impaired immunity with ↑ risk of infections

• Chronic anemia

• Thrombocytopenia with risk of hemorrhage

• Hyperleukocytosis​

  • ​Leukostasis, disseminated intravascular coagulopathy (DIC), tumor lysis syndrome (TLS)

  • Bleeding, thromboembolic events, neurologic & pulmonary complications

  • TLS: hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, acute renal failure

• Possible bone marrow transplantation with risk of graft vs host disease

• Chemotherapy with end-organ dysfunction

  • Doxocubicin (cardiomyopathy)