Acute Leukemia 

 

 

 

Considerations

 

  • Impaired immunity with ↑ risk of infections

  • Chronic anemia

  • Thrombocytopenia with risk of hemorrhage

  • Hyperleukocytosis​

    • ​Leukostasis, disseminated intravascular coagulopathy (DIC), tumor lysis syndrome (TLS)

    • Bleeding, thromboembolic events, neurologic & pulmonary complications

    • TLS: hyperuricemia, hyperkalemia, hyperphosphatemia, hypocalcemia, acute renal failure

  • Possible bone marrow transplantation with risk of graft vs host disease

  • Chemotherapy with end-organ dysfunction

    • Doxocubicin (cardiomyopathy)